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Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

Signal Transduction and Targeted Therapy

Bei Wang, Lujin Wu, Jing Chen, Lingli Dong, Chen Chen, Zheng Wen, Jiong Hu, Ingrid Fleming, Dao Wen Wang

Citations:

988

References:

545

Abstract

Abstract The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzy...

Keywords

Metabolism

Computational biology

Metabolic pathway

Arachidonic acid metabolism

Chemistry

Biology

Bioinformatics

Biochemistry

Arachidonic acid

Enzyme

Sustainable Development Goals (SDG)

Good health and well-being

2021

Review

Open Access

Institution

Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Huazhong University of Science and Technology, Hubei Province, Wuhan, China,

Tongji Hospital,

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany

Publisher

Springer Nature

2-Y Citation Average

34.422

DOI

https://doi.org/10.1038/s41392-020-00443-w

Language

Country

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

Signal Transduction and Targeted Therapy

Bei Wang, Lujin Wu, Jing Chen, Lingli Dong, Chen Chen, Zheng Wen, Jiong Hu, Ingrid Fleming, Dao Wen Wang

Citations:

988

References:

545

Abstract

Abstract The arachidonic acid (AA) pathway plays a key role in cardiovascular biology, carcinogenesis, and many inflammatory diseases, such as asthma, arthritis, etc. Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2), which is in turn further metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) and cytochrome P450 (CYP) enzy...

Keywords

Metabolism

Computational biology

Metabolic pathway

Arachidonic acid metabolism

Chemistry

Biology

Bioinformatics

Biochemistry

Arachidonic acid

Enzyme

Sustainable Development Goals (SDG)

Good health and well-being

2021

Review

Open Access

Institution

Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Huazhong University of Science and Technology, Hubei Province, Wuhan, China,

Tongji Hospital,

Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany

Publisher

Springer Nature

2-Y Citation Average

34.422

DOI

https://doi.org/10.1038/s41392-020-00443-w

Language

Country