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Mechanical Allodynia and Thermal Hyperalgesia in Diabetic Mice and Neurodegenerative Changes in the Spinal Cord and Sciatic Nerves: Modulation by Topiramate

Abstract
Background: Diabetes-related pathological alterations in body organs may take place due to immunological reactions and inflammatory/oxidative burden. Aim of Study: The current study aimed to test the neuropro-tective effect of topiramate in an animal model of peripheral di-abetic neuropathy (DN) and test its ability to suppress the spinal cord inflammatory burden and glial reactivity. Material and...
Subjects
Topiramate
Spinal cord
Sciatic nerve
Hyperalgesia
Medicine
Neuropathic pain
Neuroprotection
Peripheral neuropathy
Allodynia
Nociception
Anesthesia
Endocrinology
Internal medicine
Diabetes mellitus
Epilepsy
Receptor
Psychiatry
Sustainable Development Goals (SDG)
Zero hunger


pdf file

Mechanical Allodynia and Thermal Hyperalgesia in Diabetic Mice and Neurodegenerative Changes in the Spinal Cord and Sciatic Nerves: Modulation by Topiramate
pdf file

Mechanical Allodynia and Thermal Hyperalgesia in Diabetic Mice and Neurodegenerative Changes in the Spinal Cord and Sciatic Nerves: Modulation by Topiramate

Abstract
Background: Diabetes-related pathological alterations in body organs may take place due to immunological reactions and inflammatory/oxidative burden. Aim of Study: The current study aimed to test the neuropro-tective effect of topiramate in an animal model of peripheral di-abetic neuropathy (DN) and test its ability to suppress the spinal cord inflammatory burden and glial reactivity. Material and...
Subjects
Topiramate
Spinal cord
Sciatic nerve
Hyperalgesia
Medicine
Neuropathic pain
Neuroprotection
Peripheral neuropathy
Allodynia
Nociception
Anesthesia
Endocrinology
Internal medicine
Diabetes mellitus
Epilepsy
Receptor
Psychiatry
Sustainable Development Goals (SDG)
Zero hunger


pdf file