The Role of Colchicine in the Prevention of Bleomycin-Induced Pulmonary Fibrosis in Rats

Sarah A. Arakib, Mohammed Abdel Hay Autifi, Eman A. Elsawaf, Alsayed A. Abdelhady, Manal H. AL Badawi

Abstract

Background: Lung fibrosis is the most popular and serious sequel of interstitial inflammatory diseases and may lead to respiratory failure in critical cases with a mortality rate of 10% to 20%. Its etiology includes chemicals, infections, radiation, allergens, drugs such as bleomycin (BLM), and as a result of the coronavirus disease 2019 (COVID-19). Aim of the work: The purpose of the present work...

Subjects

Colchicine

Bleomycin

Pulmonary fibrosis

Medicine

Trichrome

Masson's trichrome stain

Fibrosis

Lung

Pathology

Interstitial lung disease

Pulmonary toxicity

H&E stain

Immunohistochemistry

Internal medicine

Chemotherapy

Sustainable Development Goals (SDG)

Good health and well-being

2024

Article

Institution

Anatomy and embryology department, faculty of Medicine, Helwan University,

Embryology Department Faculty of Medicine Al-azhar University Cairo, Egypt

Publisher

Lippincott Williams & Wilkins

Journal Rank

0.158

DOI

https://doi.org/10.21608/ejh.2024.340347.2182

Language

en

Country

Egypt

Primary Source

The Role of Colchicine in the Prevention of Bleomycin-Induced Pulmonary Fibrosis in Rats

Primary Source

The Role of Colchicine in the Prevention of Bleomycin-Induced Pulmonary Fibrosis in Rats

The Egyptian Journal of Histology

Sarah A. Arakib, Mohammed Abdel Hay Autifi, Eman A. Elsawaf, Alsayed A. Abdelhady, Manal H. AL Badawi

Abstract

Background: Lung fibrosis is the most popular and serious sequel of interstitial inflammatory diseases and may lead to respiratory failure in critical cases with a mortality rate of 10% to 20%. Its etiology includes chemicals, infections, radiation, allergens, drugs such as bleomycin (BLM), and as a result of the coronavirus disease 2019 (COVID-19). Aim of the work: The purpose of the present work...