Malaria remains a devastating parasitic disease of the tropics, with reported decreased sensitivity to all the available drugs.Spurred by the previous literature and computational studies against four plasmodium proteases, three quinolinyl chalcone derivatives; 3-prop-2-en-1-one (P4) and 3-(2-chloro-6-methoxyquinolin-3-yl)-1-(2, 3, 4-trimethoxyphenyl) prop-2-en-1-one (P5) were synthesized and eval...
Malaria remains a devastating parasitic disease of the tropics, with reported decreased sensitivity to all the available drugs.Spurred by the previous literature and computational studies against four plasmodium proteases, three quinolinyl chalcone derivatives; 3-prop-2-en-1-one (P4) and 3-(2-chloro-6-methoxyquinolin-3-yl)-1-(2, 3, 4-trimethoxyphenyl) prop-2-en-1-one (P5) were synthesized and eval...