Fluoroquinolones (FQs) are broad-spectrum, synthetic antibiotics that inhibit bacterial DNA synthesis. FQs directly block DNA synthesis in the bacterial cell via inhibition the activity of two tetrameric, ATPdependent, homologous type II topoisomerase enzymes: topoisomerase II-called DNA gyrase and topoisomerase IV. FQs are also active against eukaryotic topoisomerase II. This property results in ...
Fluoroquinolones (FQs) are broad-spectrum, synthetic antibiotics that inhibit bacterial DNA synthesis. FQs directly block DNA synthesis in the bacterial cell via inhibition the activity of two tetrameric, ATPdependent, homologous type II topoisomerase enzymes: topoisomerase II-called DNA gyrase and topoisomerase IV. FQs are also active against eukaryotic topoisomerase II. This property results in ...
Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for the management of hypertension. The present study aimed to investigate...