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Synthesis and characterization of a new spirooxindole grafted pyrrolidino/piperidine moiety

Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences

yasmine abdel Aziz, Gehad Lotfy Gehad Lotfy, Mohamed M. Said Mohamed M. Said, El Sayed H. El Ashry El Sayed H. El Ashry, El Sayed H. El Tamany El Sayed H. El Tamany, Saied M. Soliman Saied M. Soliman, Matti Haukka Matti Haukka, Assem Assem Barakat

Citations:

3

References:

16

Abstract

In this text, we synthesized and characterized a new spirooxindole grafted pyrrolidino/piperidine moieties.The new hit obtained via one-pot reaction of the chalcone based cyclohexanone with the isatin and (R)-piperidine-2-carboxylic acid in MeOH under reflux for 48 h.The compound exclusively obtained in regio-selective and diastereo-selective manner.The chemical feature of the target compound is c...

Keywords

Piperidine

Moiety

Characterization (materials science)

Chemistry

Combinatorial chemistry

Organic chemistry

Materials science

Nanotechnology

Sustainable Development Goals (SDG)

Clean water and sanitation

2021

Article

Open Access

Institution

Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.,

2Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria 21321, Egypt.,

5Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia.

2-Y Citation Average

0.42

DOI

https://doi.org/10.21608/rpbs.2021.50391.1079

Language

Country

Synthesis and characterization of a new spirooxindole grafted pyrrolidino/piperidine moiety

Synthesis and characterization of a new spirooxindole grafted pyrrolidino/piperidine moiety

Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences

yasmine abdel Aziz, Gehad Lotfy Gehad Lotfy, Mohamed M. Said Mohamed M. Said, El Sayed H. El Ashry El Sayed H. El Ashry, El Sayed H. El Tamany El Sayed H. El Tamany, Saied M. Soliman Saied M. Soliman, Matti Haukka Matti Haukka, Assem Assem Barakat

Citations:

3

References:

16

Abstract

In this text, we synthesized and characterized a new spirooxindole grafted pyrrolidino/piperidine moieties.The new hit obtained via one-pot reaction of the chalcone based cyclohexanone with the isatin and (R)-piperidine-2-carboxylic acid in MeOH under reflux for 48 h.The compound exclusively obtained in regio-selective and diastereo-selective manner.The chemical feature of the target compound is c...

Keywords

Piperidine

Moiety

Characterization (materials science)

Chemistry

Combinatorial chemistry

Organic chemistry

Materials science

Nanotechnology

Sustainable Development Goals (SDG)

Clean water and sanitation

2021

Article

Open Access

Institution

Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt.,

2Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426, Alexandria 21321, Egypt.,

5Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia.

2-Y Citation Average

0.42

DOI

https://doi.org/10.21608/rpbs.2021.50391.1079

Language

Country